Yoram Vodovotz

From tissues morphing in development to microbes competing in a bioreactor, biology is inherently emergent. Multi-agent simulations — from platforms like BioDynaMo, CompuCell3D, and BIO-LGCA — are now powerful enough to model billions of interacting agents, capturing diffusion, metabolism, migration, and signaling with physical fidelity. Synthetic biologists are using these frameworks to probe design limits before moving to the lab, asking questions like: How far can diffusion alone carry a signaling molecule? What metabolic bottlenecks emerge in crowded cells? And how do engineered traits play out at population scale? This session will spotlight how agent-based models are becoming essential design environments for synthetic biology, helping teams test hypotheses virtually, anticipate failure modes, and translate biology into an engineering discipline rooted in predictive, quantitative simulation.