SynBioBeta Speaker

Gordon Freedman

MitoWorld

Publisher

Gordon Freedman is the founder and president of the National Laboratory for Education Transformation (NLET, www.NLET.org), a California-based nonprofit that now anchors several initiatives driving what he calls the “mitochondrial revolution” in medicine and health. Through NLET, he founded MitoWorld.org as a neutral, science-forward public gateway to mitochondrial biology, curating expert content, interviews, and explainers that connect cutting-edge research to clinicians, patients, investors, and policy makers.Building on this foundation, Freedman launched MITOS.org as an emerging global collaboration platform focused on translating mitochondrial science into diagnostics, therapeutics, and prevention strategies. MITOS convenes researchers, clinicians, and technology partners to identify high-value opportunities in areas such as metabolic disease, neurodegeneration, immune dysfunction, aging, and women’s health, while emphasizing rigorous validation and cross-disciplinary collaboration.Freedman’s work sits at the intersection of biomedicine, data, and systems transformation. Drawing on his background in large-scale education and workforce innovation, he is building new narratives, tools, and coalitions to move mitochondria from a niche specialty to a central organizing framework for understanding human biology and environmental stress. Through MitoWorld.org and MITOS.org, he is assembling scientific advisory networks, mapping the global mitochondrial research landscape, and designing communication and funding strategies that can support the next generation of mitochondrial diagnostics and interventions.At SynBioBeta 2026, Freedman’s session on mitochondrial advances will highlight how synthetic biology, precision measurement, and high-throughput screening can unlock mitochondrial mechanisms as platforms for drug discovery, cell and gene therapies, and systems-level models of human health. His goal is to help bridge pioneering mitochondrial science with the entrepreneurial, engineering, and investment communities needed to scale mitochondrial innovation for global impact.

Sessions Featuring

Gordon

This Year

Breakout Session

•

4:30 PM

-

5:15 PM

Longevity

Mitochondrial Transplantation and Genome Editing: Engineering the Metabolic Engine of Complex Life

Mitochondria are often pigeon-holed as the "powerhouse of the cell", giving the false impression that their primary role is as an ATP generator passively responding to the energetic demands of their environment. This is far from the truth. The mitochondria exist as a dynamic network that senses, integrates, and transduces biochemical, energetic, and physical signals, and these signals shape cell fate, lifespan, cancer risk, and more. This session explores emerging tools and methods to edit the small, maternally-inherited, circular mitochondrial genome present in dozens-to-hundreds of copies per cell as a means to prevent mitochondrial disease and optimize metabolic fitness. Additionally, we will discuss the promise of mitochondrial transplantation methodologies as a therapeutic intervention and to discuss the possible routes for mitochondrial metabolic engineering and a range of synthetic developments.

Featuring

Mariëlle van Kooten

Powerhouse Bio

CEO

Mitochondrial bioengineer

Colwyn Headley

Stanford University

Instructor

Mitochondrial-transplantation researcher targetting aging-immune heart disease

Cecilia Giulivi

UC Davis

Professor

Ryan Olf

ARIA

Programme Director

Physicist chasing moonshots from quantum gases to biotech.

Gordon Freedman

MitoWorld

Publisher

Mitochondrial-medicine ecosystem builder

Breakout Session

•

4:30 PM

-

5:15 PM

Longevity

Mitochondrial Transplantation and Genome Editing: Engineering the Metabolic Engine of Complex Life

Mitochondria are often pigeon-holed as the "powerhouse of the cell", giving the false impression that their primary role is as an ATP generator passively responding to the energetic demands of their environment. This is far from the truth. The mitochondria exist as a dynamic network that senses, integrates, and transduces biochemical, energetic, and physical signals, and these signals shape cell fate, lifespan, cancer risk, and more. This session explores emerging tools and methods to edit the small, maternally-inherited, circular mitochondrial genome present in dozens-to-hundreds of copies per cell as a means to prevent mitochondrial disease and optimize metabolic fitness. Additionally, we will discuss the promise of mitochondrial transplantation methodologies as a therapeutic intervention and to discuss the possible routes for mitochondrial metabolic engineering and a range of synthetic developments.

Featuring

Mariëlle van Kooten

Powerhouse Bio

CEO

Mitochondrial bioengineer

Colwyn Headley

Stanford University

Instructor

Mitochondrial-transplantation researcher targetting aging-immune heart disease

Cecilia Giulivi

UC Davis

Professor

Ryan Olf

ARIA

Programme Director

Physicist chasing moonshots from quantum gases to biotech.

Gordon Freedman

MitoWorld

Publisher

Mitochondrial-medicine ecosystem builder

Previous Speakers Include