Marieke Klijn

Standard bioreactors often lack the instrumentation required to rapidly monitor cell physiology, leaving critical gaps in our understanding of scale-up dynamics. This session presents active projects from the Schmidt Sciences’ Sensors for Biomanufacturing Program designed to address this challenge through novel sensing modalities. Spanning from near real-time intracellular measurements to non-invasive off-gas fingerprinting, the panel brings together technology developers and industrial bioprocess experts to discuss the translation of these tools from the lab to the plant floor. Together, we will critically evaluate the utility of high-dimensional metabolic data and explore the engineering requirements for integrating physics-based sensors and machine learning into existing biomanufacturing workflows.